Molecular Biology: The discovery of DNA, evidences indication DNA as the genetic material, types of DNA, closed super coiled DNA, denaturing and renaturing of DNA, DNA hybridization
Discovery:- The Swiss scientist Friedrich Miescher discovered nucleic acid and fisrt naming it nuclein in 1868. Later in 1889 Altmann introduced the term nucleic acid. Nature of Genetic Material:- • A genetic material must:- - Be able to generate its replica (Replication). - Chemically and structurally be stable. - Provide the mutations that are required for evolution. - Be able to express itself as ‘Mendelian Characters’. • DNA versus RNA:- - DNA is stable while RNA is unstable. Due to unstable nature of RNA, RNA viruses mutate and evolve faster. - For the storage of genetic information DNA is better due to its stability. But for the transmission of genetic information, RNA is better. - RNA can directly code for the protein synthesis, hence can easily express the characters. DNA is dependent on RNA for protein synthesis. - The 2 DNA strands are complementary. On h...